Adiponectin protects rat hippocampal neurons against excitotoxicity
نویسندگان
چکیده
منابع مشابه
Adiponectin Protects against Glutamate-Induced Excitotoxicity via Activating SIRT1-Dependent PGC-1α Expression in HT22 Hippocampal Neurons
Glutamate- (Glu-) induced excitotoxicity plays a critical role in stroke. This study aimed to investigate the effects of APN on Glu-induced injury in HT22 neurons. HT22 neurons were treated with Glu in the absence or the presence of an APN peptide. Cell viability was assessed using the MTT assay, while cell apoptosis was evaluated using TUNEL staining. Levels of LDH, MDA, SOD, and GSH-Px were d...
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ژورنال
عنوان ژورنال: AGE
سال: 2010
ISSN: 0161-9152,1574-4647
DOI: 10.1007/s11357-010-9173-5